The top films at the North American Box Office






LOS ANGELES (Reuters) – Following are the top 10 movies at North American box offices for the weekend starting February 1, led by Warm Bodies at No. 1, according to studio estimates compiled by Reuters. 1 (*) Warm Bodies…………………………..$ 20.0 million 2 (1) Hansel and Gretel……………………..$ 9.2 million 3 (3) Silver Linings Playbook………………..$ 8.1 million 4 (2) Mama…………………………………$ 6.7 million 5 (4) Zero Dark Thirty………………………$ 5.3 million 6 (*) Bullet to the Head…………………….$ 4.5 million 7 (5) Parker……………………………….$ 3.2 million 8 (6) Django Unchained………………………$ 3.0 million 9 (10)Les Miserables………………………..$ 2.4 million 10 (11)Lincoln………………………………$ 2.4 million NOTES: (*) = new release


CUMULATIVE TOTALS: Lincoln…………………………………..$ 170.8 million Django Unchained…………………………..$ 151.0 million Les Miserables…………………………….$ 141.5 million Silver Linings Playbook…………………….$ 80.4 million Zero Dark Thirty…………………………..$ 77.8 million Mama……………………………………..$ 58.3 million Hansel and Gretel: Witch Hunters…………….$ 34.5 million Warm Bodies……………………………….$ 20.0 million Parker……………………………………$ 12.4 million Bullet to the Head…………………………$ 4.5 million






Hansel & Gretel: Witch Hunters” was distributed by Paramount Pictures, a unit of Viacom Inc. “Zero Dark Thirty” was released by Sony Corp’s movie studio. “Warm Bodies” and “The Last Stand” were distributed by Lions Gate Entertainment. “Bullet to the Head” was released by Warner Bros, a unit of Time Warner Inc “Django Unchained” and “Silver Linings Playbook” were distributed by Weinstein Co. “Les Miserables” and “Mama” were distributed by Universal Pictures, a unit of Comcast Corp.


(Reporting By Ronald Grover and Andrea Burzynski; Editing by Sandra Maler)


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Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


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Medicines Co. Licenses Rights to Cholesterol Drug



The drug, known as ALN-PCS, inhibits a protein in the body known as PCSK9. Such drugs might one day be used to treat millions of people who do not achieve sufficient cholesterol-lowering from commonly used statins, such as Lipitor.


The Medicines Company will pay $25 million initially and as much as $180 million later if certain development and sales goals are met, under the deal expected to be formally announced Monday. It will also pay Alnylam, which is based in Cambridge, Mass., double-digit royalties on global sales.


That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.


The team of Sanofi and Regeneron Pharmaceuticals is already entering the third and final stage of trials with their PCSK9 inhibitor, as is Amgen. Pfizer and Roche are in midstage trials.


ALN-PCS is different from the other drugs. It uses a gene-silencing mechanism called RNA interference, aimed at shutting off production of the PCSK9 protein. The other drugs are proteins called monoclonal antibodies that inhibit the action of PCSK9 after it has been formed.


Alnylam and the Medicines Company hope that turning off the faucet, as it were, will be more efficient than mopping the floor, allowing their drug to be given less frequently and in smaller amounts.


But that has yet to be proved. No drug using RNA interference has reached the market.


The Medicines Company, based in Parsippany, N.J., generates almost all of its revenue from one product — Angiomax, an anticlotting drug used when patients receive stents to open clogged arteries.


Dr. Clive A. Meanwell, chief executive of the company, said that PCSK9 inhibitors are likely to be used at first mainly by patients with severe lipid problems under the care of interventional cardiologists, the same doctors who use Angiomax. “It really is quite adjacent to what we do,” he said.


The Medicines Company licensed Angiomax from Biogen Idec, where the drug was invented and initially developed under a team led by Dr. John M. Maraganore, who is now the chief executive of Alnylam.


“It’s a bit like getting the band back together,” Dr. Maraganore said.


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'Argo' director Ben Affleck Wins DGA Award









Ben Affleck was named outstanding director for "Argo" at the 65th Annual Directors Guild of America Awards, which were held Saturday night at the Ray Dolby Ballroom at Hollywood & Highland.


The win solidifies "Argo" as an Oscar frontrunner, after the film also claimed key honors from the Screen Actors and Producers guilds last weekend.


"I don't this makes me a real director, but I think it means I'm on my way," Affleck said in a speech.





The other nominees for the feature directing award were Kathryn Bigelow for "Zero Dark Thirty," Tom Hooper for "Les Miserables," Ang Lee for "Life of Pi" and Steven Spielberg for "Lincoln."

The DGA award for feature directing has traditionally been a reliable indicator of who will win the directing Oscar -- only six times since the DGA Awards began in 1948 have the two honors differed.


But this year's Oscar directing race has been a bit of a head-scratcher--Affleck was not nominated, despite his film receiving multiple nominations from the Academy in other categories. Bigelow and Hooper were also snubbed.


The DGA is a larger body than the Academy's directing branch, representing 15,000 members, many of them in television.


The ceremony's television winners included Rian Johnson, who earned the drama series award for directing the "Fifty-One" episode of "Breaking Bad"; Lena Dunham, who collected the comedy series award for directing the pilot of "Girls"; and Jay Roach, who took the movies for television/miniseries prize for "Game Change" on HBO.


The evening's winner for documentary directing was Malik Bendjelloul, for the "Searching For Sugarman."


A lifetime achievement award was presented to "One Flew Over the Cuckoo's Nest" and "The People vs. Larry Flynt" director Milos Forman.


Host Kelsey Grammer kept the evening light, making jokes about Manti Te'o, Mel Gibson and Ron Jeremy, as well as some of the nominees in the room.


Grammer said to Bigelow, whose movie has been at the center of a controversy over forced interrogation, "Waiting so patiently to see if your name will be called, it must be torture for you."


All of the evening's feature directing nominees received a medallion from the DGA, most of them presented after an adoring speech. Martin Short, however, delivered Spielberg's medallion in an irreverent and sometimes bawdy address.


"I like my champagne like I like my women," Short said. "Compliments of the DGA."


When Spielberg stood to accept the honor--receiving the night's first full-house standing ovation--he reacted with amusement.


"When you tell your assistant to contact Marty about presenting you with the DGA medallion," Spielberg said, "You just assume she knows you're talking about Marty Scorsese."


ALSO


Academy doesn't follow the script in directors' race


Santa Barbara Film Fest sees itself as Oscar harbinger


Is 'Argo' poised to deliver a shocker at Directors Guild Awards?





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The World's Tweets Light Up the Globe in Stunning Live Visualization




It’s simple, but lovely. Web designer Franck Ernewein‘s real-time Twitter visualization, Tweetping, drops a bright pixel at the location of every tweet in the world, starting as soon as you open the page.



The result is a constantly changing image that grows to look like a nighttime satellite shot, bright spots swarming over the most developed areas. But Ernewein has packaged it all in a subtly interactive visualization that avoids distracting the viewer while still imparting a great amount of information.



Meanwhile, a selection of tweets are projected, along with latest hashtags and mentions, all while tracking total tweets, words, and characters. The length of the two gray lines on the display represent the number of characters and words in each tweet.



Though it’s one of the most beautiful, Tweetping is far from the first to display geotagged tweet information; coders have built sites to display election tweets, adjustable parameter maps, and even 3-D visualizations.



Tweetping even represents Antarctica, but not the ISS. And there’s no pause button; like Twitter itself, Tweetping’s data accrues incessantly; there’s no off switch but the back button.





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‘Girls,’ ‘Sugar Man’ earn Directors Guild honors






LOS ANGELES (AP) — “Girls” star Lena Dunham has won the TV comedy directing prize from the Directors Guild of America, while the musical portrait “Searching for Sugar Man” earned the documentary award.


Dunham won Saturday for directing the pilot of the show, which focuses on the lives of a group of girls in their 20s.






“It is such an unbelievable honor to be in the company of the people in this room, who have made me want to do this with my life,” Dunham said.


Malik Bendjelloul won the documentary award for “Sugar Man,” his study of the fate of critically acclaimed but obscure 1970s singer-songwriter Rodriquez. The film also is nominated for best documentary at the Feb. 24 Academy Awards.


Among other early TV winners:


— Musical variety: Glenn Weiss, “The 66th Annual Tony Awards.”


— Daytime serial: Jill Mitwell, “One Life to Live.”


— Children’s program: Paul Hoen, “Let It Shine.”


The Directors Guild honors continued Hollywood’s strange awards season, which could culminate with a big Oscar win for Ben Affleck‘s “Argo.” The guild’s prize for best director typically is a final blessing for the film that goes on to win best-picture and director at the Academy Awards.


Affleck can go only one-for-two at the Oscars, though. He’s up for the film honor at the Directors Guild, and “Argo” is looking like the best-picture favorite at the Oscars. But the director’s branch of the Academy of Motion Picture Arts and Sciences overlooked him and several other key filmmakers for an Oscar directing slot.


The guild and Oscar directing lineups usually match up closely, but they have little in common this season, with only Steven Spielberg for “Lincoln” and Ang Lee for “Life of Pi” nominated at both shows.


Along with them and Affleck, the guild nominated Kathryn Bigelow for “Zero Dark Thirty” and Tom Hooper for “Les Miserables.” At the Oscars, Spielberg and Lee are joined in the directing category by Michael Haneke for “Amour,” David O. Russell for “Silver Linings Playbook” and Benh Zeitlin for “Beasts of the Southern Wild.”


Director Norman Jewison, the guild’s 2010 lifetime-achievement prize winner, presented Bigelow with her nomination plaque and noted the incongruity of the Oscar best-picture field, which has nine nominees, while there are only five directing slots.


“So apparently, there were four films that were directed by themselves,” Jewison said.


With 12 Oscar nominations, Spielberg’s Civil War saga initially looked like the Oscar favorite over such other potential favorites as “Argo,” ”Les Miserables” and “Zero Dark Thirty,” since films generally have little chance of winning best picture if they are not nominated for best director. Only three films have done it in 84 years, most recently 1989′s best-picture champ “Driving Miss Daisy,” which failed to earn a directing nomination for Bruce Beresford.


But Affleck’s “Argo,” in which he also stars as a CIA operative who hatches a bold plan to rescue six Americans during the hostage crisis in Iran, has swept up all the major awards since the Oscar nominations. “Argo” won best drama and director at the Golden Globes and top film honors from the Screen Actors Guild and the Producers Guild of America.


Many of the same film professionals who vote in guild awards also cast ballots for the Oscars. If Affleck wins at the Directors Guild awards, it will be a strong sign that “Argo” has the inside track for the best-picture Oscar.


Affleck may have a bit of newcomer’s edge at the guild, where he’s the only first-time nominee. Spielberg has won the guild prize a record three times, for “The Color Purple,” ”Schindler’s List” and “Saving Private Ryan.” Lee has won twice, for “Crouching Tiger, Hidden Dragon” and “Brokeback Mountain,” while Bigelow won three years ago for “The Hurt Locker” and Hooper won two years ago for “The King’s Speech.”


A win for Affleck would nick the guild’s record as a strong forecast for the eventual directing recipient at the Oscars. Only six times in the 64-year history of the guild awards has the winner there failed to follow up with an Oscar. It would be No. 7 if Affleck wins Saturday, since he’s not up for best director at the Oscars.


Peer loyalty might play in Affleck’s favor at the Oscars. The acting branch in particular, the largest block of the academy’s 5,900 members, might really throw its weight behind “Argo” because of Affleck’s directing snub. Actors love it when one of their own moves into a successful directing career, and Affleck — who’s rarely earned raves for his dramatic chops — also delivers one of his best performances in “Argo.”


Affleck has had no traction in acting honors this season, and he’s joked that no one considered it a snub when he wasn’t nominated for best actor. So a best-picture vote for “Argo” might be viewed as making right his omission from the directing lineup and acknowledging what a double-threat talent he’s become in front of and behind the camera.


A best-picture prize also would send Affleck home with an Oscar. The award would go to the producers of “Argo”: George Clooney, Grant Heslov and Affleck.


But it’s not as though Affleck has never gotten his due at Hollywood awards before. He and Matt Damon jump-started their careers with 1997′s “Good Will Hunting,” for which they shared a screenplay Oscar.


___


AP Entertainment Writer Sandy Cohen contributed to this report.


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Concerns About A.D.H.D. Practices and Amphetamine Addiction


Before his addiction, Richard Fee was a popular college class president and aspiring medical student. "You keep giving Adderall to my son, you're going to kill him," said Rick Fee, Richard's father, to one of his son's doctors.







VIRGINIA BEACH — Every morning on her way to work, Kathy Fee holds her breath as she drives past the squat brick building that houses Dominion Psychiatric Associates.










Andrea Mohin/The New York Times

MENTAL HEALTH CLINIC Dominion Psychiatric Associates in Virginia Beach, where Richard Fee was treated by Dr. Waldo M. Ellison. After observing Richard and hearing his complaints about concentration, Dr. Ellison diagnosed attention deficit hyperactivity disorder and prescribed the stimulant Adderall.






It was there that her son, Richard, visited a doctor and received prescriptions for Adderall, an amphetamine-based medication for attention deficit hyperactivity disorder. It was in the parking lot that she insisted to Richard that he did not have A.D.H.D., not as a child and not now as a 24-year-old college graduate, and that he was getting dangerously addicted to the medication. It was inside the building that her husband, Rick, implored Richard’s doctor to stop prescribing him Adderall, warning, “You’re going to kill him.”


It was where, after becoming violently delusional and spending a week in a psychiatric hospital in 2011, Richard met with his doctor and received prescriptions for 90 more days of Adderall. He hanged himself in his bedroom closet two weeks after they expired.


The story of Richard Fee, an athletic, personable college class president and aspiring medical student, highlights widespread failings in the system through which five million Americans take medication for A.D.H.D., doctors and other experts said.


Medications like Adderall can markedly improve the lives of children and others with the disorder. But the tunnel-like focus the medicines provide has led growing numbers of teenagers and young adults to fake symptoms to obtain steady prescriptions for highly addictive medications that carry serious psychological dangers. These efforts are facilitated by a segment of doctors who skip established diagnostic procedures, renew prescriptions reflexively and spend too little time with patients to accurately monitor side effects.


Richard Fee’s experience included it all. Conversations with friends and family members and a review of detailed medical records depict an intelligent and articulate young man lying to doctor after doctor, physicians issuing hasty diagnoses, and psychiatrists continuing to prescribe medication — even increasing dosages — despite evidence of his growing addiction and psychiatric breakdown.


Very few people who misuse stimulants devolve into psychotic or suicidal addicts. But even one of Richard’s own physicians, Dr. Charles Parker, characterized his case as a virtual textbook for ways that A.D.H.D. practices can fail patients, particularly young adults. “We have a significant travesty being done in this country with how the diagnosis is being made and the meds are being administered,” said Dr. Parker, a psychiatrist in Virginia Beach. “I think it’s an abnegation of trust. The public needs to say this is totally unacceptable and walk out.”


Young adults are by far the fastest-growing segment of people taking A.D.H.D medications. Nearly 14 million monthly prescriptions for the condition were written for Americans ages 20 to 39 in 2011, two and a half times the 5.6 million just four years before, according to the data company I.M.S. Health. While this rise is generally attributed to the maturing of adolescents who have A.D.H.D. into young adults — combined with a greater recognition of adult A.D.H.D. in general — many experts caution that savvy college graduates, freed of parental oversight, can legally and easily obtain stimulant prescriptions from obliging doctors.


“Any step along the way, someone could have helped him — they were just handing out drugs,” said Richard’s father. Emphasizing that he had no intention of bringing legal action against any of the doctors involved, Mr. Fee said: “People have to know that kids are out there getting these drugs and getting addicted to them. And doctors are helping them do it.”


“...when he was in elementary school he fidgeted, daydreamed and got A’s. he has been an A-B student until mid college when he became scattered and he wandered while reading He never had to study. Presently without medication, his mind thinks most of the time, he procrastinated, he multitasks not finishing in a timely manner.”


Dr. Waldo M. Ellison


Richard Fee initial evaluation


Feb. 5, 2010


Richard began acting strangely soon after moving back home in late 2009, his parents said. He stayed up for days at a time, went from gregarious to grumpy and back, and scrawled compulsively in notebooks. His father, while trying to add Richard to his health insurance policy, learned that he was taking Vyvanse for A.D.H.D.


Richard explained to him that he had been having trouble concentrating while studying for medical school entrance exams the previous year and that he had seen a doctor and received a diagnosis. His father reacted with surprise. Richard had never shown any A.D.H.D. symptoms his entire life, from nursery school through high school, when he was awarded a full academic scholarship to Greensboro College in North Carolina. Mr. Fee also expressed concerns about the safety of his son’s taking daily amphetamines for a condition he might not have.


“The doctor wouldn’t give me anything that’s bad for me,” Mr. Fee recalled his son saying that day. “I’m not buying it on the street corner.”


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Iceland, Prosecutor of Bankers, Sees Meager Returns


Ilvy Njiokiktjien for The New York Times


"Greed is not a crime. But the question is: where does greed lead?" said Olafur Hauksson, a special prosecutor in Reykjavik.







REYKJAVIK, Iceland — As chief of police in a tiny fishing town for 11 years, Olafur Hauksson developed what he thought was a basic understanding of the criminal mind. The typical lawbreaker, he said, recalling his many encounters with small-time criminals, “clearly knows that he crossed the line” and generally sees “the difference between right and wrong.”




Today, the burly, 48-year-old former policeman is struggling with a very different sort of suspect. Reassigned to Reykjavik, the Icelandic capital, to lead what has become one of the world’s most sweeping investigation into the bankers whose actions contributed to the global financial crisis in 2008, Mr. Hauksson now faces suspects who “are not aware of when they crossed the line” and “defend their actions every step of the way.”


With the global economy still struggling to recover from the financial maelstrom five years ago, governments around the world have been criticized for largely failing to punish the bankers who were responsible for the calamity. But even here in Iceland, a country of just 320,000 that has gone after financiers with far more vigor than the United States and other countries hit by the crisis, obtaining criminal convictions has proved devilishly difficult.


Public hostility toward bankers is so strong in Iceland that “it is easier to say you are dealing drugs than to say you’re a banker,” said Thorvaldur Sigurjonsson, the former head of trading for Kaupthing, a once high-flying bank that crumbled. He has been called in for questioning by Mr. Hauksson’s office but has not been charged with any wrongdoing.


Yet, in the four years since the Icelandic Parliament passed a law ordering the appointment of an unnamed special prosecutor to investigate those blamed for the country’s spectacular meltdown in 2008, only a handful of bankers have been convicted.


Ministers in a left-leaning coalition government elected after the crash agree that the wheels of justice have ground slowly, but they call for patience, explaining that the process must follow the law, not vengeful passions.


“We are not going after people just to satisfy public anger,” said Steingrimur J. Sigfusson, Iceland’s minister of industry, a former finance minister and leader of the Left-Green Movement that is part of the governing coalition.


Hordur Torfa, a popular singer-songwriter who helped organize protests that forced the previous conservative government to resign, acknowledged that “people are getting impatient” but said they needed to accept that “this is not the French Revolution. I don’t believe in taking bankers out and hanging them or shooting them.”


Others are less patient. “The whole process is far too slow,” said Thorarinn Einarsson, a left-wing activist. “It only shows that ‘banksters’ can get away with doing whatever they want.”


Mr. Hauksson, the special prosecutor, said he was frustrated by the slow pace but thought it vital that his office scrupulously follow legal procedure. “Revenge is not something we want as our main driver in this process. Our work must be proper today and be seen as proper in the future,” he said.


Part of the difficulty in prosecuting bankers, he said, is that the law is often unclear on what constitutes a criminal offense in high finance. “Greed is not a crime,” he noted. “But the question is: where does greed lead?”


Mr. Hauksson said it was often easy to show that bankers violated their own internal rules for lending and other activities, but “as in all cases involving theft or fraud, the most difficult thing is proving intent.”


And there are the bankers themselves. Those who have been brought in for questioning often bristle at being asked to account for their actions. “They are not used to being questioned. These people are not used to finding themselves in this situation,” Mr. Hauksson said. They also hire expensive lawyers.


The special prosecutor’s office initially had only five staff members but now has more than 100 investigators, lawyers and financial experts, and it has relocated to a big new office. It has opened about 100 cases, with more than 120 people now under investigation for possible crimes relating to an Icelandic financial sector that grew so big it dwarfed the rest of the economy.


To help ease Mr. Hauksson’s task, legislators amended the law to allow investigators easy access to confidential bank information, something that previously required a court order.


Parliament also voted to put the country’s prime minister at the time of the banking debacle on trial for negligence before a special tribunal. (A proposal to try his cabinet failed.) Mr. Hauksson was not involved in the case against the former leader, Geir H. Haarde, who last year was found guilty of failing to keep ministers properly informed about the 2008 crisis but was acquitted on more serious charges that could have resulted in a prison sentence.


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Marmot researchers raise a toast for Groundhog Day









For most Americans, Groundhog Day is a quaint oddity or a movie starring Bill Murray. For Punxsutawney Phil Sowerby, the Pennsylvania critter who'll be dragged out of his burrow Saturday by men in top hats to look for his shadow, the day must be a supreme annoyance.


But for UCLA biologist Dan Blumstein, today's midwinter observance has become a reason to throw a party in honor of a creature that scientists have studied for decades.


Groundhogs are marmots — and through marmots, scientists hope to gain insight into the social behavior of animals, how they communicate and how their interactions influence the size of their population.





And so on Friday afternoon, Blumstein and a group of 30 or so fellow "marmotophiles" gathered in a spare hallway in the university's Life Sciences building and toasted groundhogs with cans of soda as a jazz mix played in the background.


"This is really the only holiday about animal behavior," Blumstein said.


Cat-sized, sharp-toothed groundhogs have a large range — from the Southeast up into the East Coast and Midwest, across Canada and even as far north as Alaska. Also known as woodchucks, they're the largest of the 14 or 15 marmot species (scientists are still debating the precise number).


Marmots are great animals for scientists to study, Blumstein said, because they're awake during the day and they "have an address," living in burrows that researchers can stake out over time. Blumstein, who has also studied the behavior of kangaroos, wallabies, hermit crabs, sea anemones, lizards, birds and people, has spent more than 13 years observing the colonies of yellow-bellied marmots who live at the Rocky Mountain Biological Laboratory in Crested Butte, Colo.


During summers in the field, he and colleagues have trapped marmots live using horse chow as bait, tagged them with "earrings," taken samples of their blood, and recorded the size of colonies as they waxed and waned. During winter, Blumstein has held a hibernating marmot in a lab, its body temperature just a couple of degrees above freezing. "It's like a hairy rock," he said.


A groundhog roused from hibernation that appears to be "looking for his shadow" is probably displaying a typical pattern, Blumstein said. Marmots rouse periodically during the winter to urinate, and near the end of the season they start to emerge from their burrows and scope out their territory for potential mates. Males typically wake before females.


Over the years, the scientists' observations have helped them understand how certain behaviors translate into success, or failure, for the colonies. Lately, they've focused on how the higher temperatures brought on by climate change might improve, or hinder, the marmots' reproductive success.


As recently as 2010, earlier springs seemed to be helping the marmots in Colorado by increasing the length of time they could eat. But then a longer-than-usual winter caused the population to crash.


Blumstein and his team are curious to see how the marmots will fare this spring after a winter that produced less early-season snow. That snow acts as a blanket for the animals; without it, their burrows may not have maintained the right temperature for healthy hibernation.


"We want to understand the limits of their flexibility," Blumstein said. "At some point, there may be too little snow to keep them warm over the winter."


One of Blumstein's students said she was studying gene expression in the Colorado marmots. Another student, from South America, was studying how marmots react to climate. They don't have marmots — or Groundhog Day — in South America, she noted.


Matthew Petelle, a graduate student, said he was interested in "marmot personality." Some are bold and others are shy, he said, and he's trying to figure out why the shy ones survive and thrive.


"We're the enthusiasts," he said of the partygoers at the science building, admitting that he'd probably be talking about marmots even in the absence of Groundhog Day.


Behind Petelle glowered Two-Buck Chuck, a groundhog Blumstein spied near a Kansas road more than 15 years ago.


"I was trying to study it and I was thinking it was alive," he said. "Then I realized, it's really not moving."


The animal had been hit by a car and had crawled off the road to die. Blumstein brought the body back to his lab and stuffed it, with help from his wife.


Other examples of groundhog kitsch were on display as well. There was a photograph of an obese yellow-bellied marmot eating Lay's potato chips in a Utah woman's kitchen and a page from the News of the World tabloid headlined "ATTACK OF THE 100 FT MARMOT."


"We made that into T-shirts," Blumstein said.


The jovial professor said he got the idea for the annual shindigs from his mentor, Kenneth Armitage, a University of Kansas behavioral ecologist who led the Rocky Mountain Biological Laboratory marmot project for 41 years.


Armitage, now retired, said he always promised his guests he'd serve groundhog at the parties.


As in "ground hog," or sausage.


"They'd kind of look at you funny, at first," he said of his grad students. "Then you'd see this big flash of relief."


eryn.brown@latimes.com





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Twitter Hacked; Company Says 250K Users May Have Been Affected



Following a string of revelations this week from several media companies who announced they had been recently hacked, Twitter announced on Friday that it had also been the target of a sophisticated attack.


The company wrote in a blog post ironically titled “Keeping our users secure” that it detected unusual patterns this week that led it to identify attempts to access user data.


“We discovered one live attack and were able to shut it down in process moments later,” wrote Bob Lord, Twitter’s director of information security. “However, our investigation has thus far indicated that the attackers may have had access to limited user information — usernames, email addresses, session tokens and encrypted/salted versions of passwords — for approximately 250,000 users.”


As a result, the company said it had reset passwords and revoked session tokens for the accounts suspected of being affected. The company also sent an e-mail to affected users informing them that their old password was no longer valid and that they would need to create a new one.


The email, forwarded to Wired by one reader who received one, reads:


“Twitter believes that your account may have been compromised by a website or service not associated with Twitter,” it reads. “We’ve reset your password to prevent others from accessing your account.”


The email also warns users to “Avoid using websites or services that promise to get you lots of followers. These sites have been known to send spam updates and damage user accounts.”


Lord did not explain how the attackers got in and accessed the data, but said that he did not believe Twitter was the only company targeted.


“This attack was not the work of amateurs, and we do not believe it was an isolated incident,” he wrote. “The attackers were extremely sophisticated, and we believe other companies and organizations have also been recently similarly attacked. For that reason we felt that it was important to publicize this attack while we still gather information, and we are helping government and federal law enforcement in their effort to find and prosecute these attackers to make the Internet safer for all users.”


Twitter recently began bulking up its security team with a number of high-profile hires. In 2011 noted white hat hacker and security pro Moxie Marlinspike joined Twitter after the company acquired his mobile encryption firm Whisper Systems. Last September, Marlinspike helped bring on board fellow noted white hat hacker and researcher Charlie Miller.


Just two weeks ago, however, Marlinspike announced that he was leaving Twitter.


Twitter’s hack announcement Friday comes in a week crowded with announcements about media companies that have been hacked. On Thursday, the New York Times revealed that hackers, who had been inside its network for at least four months, had succeeded to steal the usernames and passwords of all of its employees in an apparent attempt to identify sources and gather other intelligence about stories related to the family of China’s prime minister.


The hackers breached the network sometime around Sept. 13 and stole the corporate passwords for every Times employee, using them to gain access to the personal computers of 53 employees, according to the report.


The hackers also broke into the email account of the newspaper’s Shanghai bureau chief, David Barboza, who conducted the investigation, as well as the email account of Jim Yardley, the paper’s South Asia bureau chief in India, who had previously worked out of Beijing.


The Times report indicated that the attack was part of a wave of attacks that appeared to come from China and were targeted against western media outlets.


The day after the Times announcement a report surfaced that the Wall Street Journal had also been hacked, followed the next day by a report that the Washington Post had also been targeted.


Update 9 pm PST: To add text of email sent to users affected by the breach.


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