DealBook: Allergan to Buy MAP Pharmaceuticals for $958 Million

Allergan has agreed to pay nearly $1 billion to acquire MAP Pharmaceuticals and gain full control of its experimental treatment for migraine headaches, the two companies announced Tuesday night.

The purchase price of $25 a share in cash is a 60 percent premium over MAP’s closing price on Tuesday of $15.58 a share. The deal, valued at $958 million in total, suggests that Allergan has considerable faith that MAP’s new migraine treatment will win regulatory approval from the Food and Drug Administration by the agency’s deadline of April 15.

The two companies said the deal had been unanimously approved by the boards of both companies and was expected to close in the second quarter.

Allergan already had the rights to help market the migraine drug, known as Levadex, in the United States and Canada, but after an acquisition it would have control of all the profits and costs globally.

Allergan is most known for Botox, a form of the botulinum toxin, which is used for cosmetic purposes as well as medical ones, including the treatment of chronic migraines with the goal of reducing the frequency of headaches. By contrast, Levadex is meant to treat migraines after they occur, making it complementary to Botox, Allergan said.

Levadex is actually a new form of an old drug, known as dihydroergotamine, or DHE, which has been used to treat severe migraine attacks for decades. DHE is typically given by intravenous infusion, requiring patients to get to a hospital at a time when many would rather remain in a dark quiet room.

Levadex, by contrast, is breathed into the lungs using an inhaler similar to one used for asthma, allowing people to use it at home.

The F.D.A. declined to approve Levadex last March, though MAP said the rejection was related to manufacturing and questions about use of the inhaler, not the safety and efficacy of the drug. It resubmitted its application, with additional data and answers to questions from the F.D.A., in October.

Levadex would be the first approved product for MAP, which is based in Mountain View, Calif.

Allergan said that if Levadex is approved by April, the transaction would dilute earnings by about 7 cents a share in 2013 and add to earnings in the second half of 2014.

Allergan was advised by Goldman Sachs and the law firm Gibson, Dunn & Crutcher. MAP was advised by Centerview Partners and the law firm Latham & Watkins.

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In Obama's inaugural speech, a sweeping liberal vision









WASHINGTON — Allowing that "our journey is not complete," President Obama offered a robust liberal vision of America in his second inaugural address, embracing gay rights, action on climate change and a substantial role for government even as he acknowledged the challenges of a bitterly divided nation.


An ocean of American flags waved under overcast skies and hundreds of thousands of faces tilted up just before noon Monday as Obama stood on the Capitol's West Front and repeated the oath of office in America's 57th presidential inauguration.


Chants of "O-ba-ma" rose, echoing from a packed National Mall. The atmosphere was festive, but the fevered excitement that welcomed America's first African American president four years ago had been toned down. Still, though the crowd appeared smaller, it may rank as one of the largest for an inaugural celebration.





In an 18-minute speech, Obama paid tribute to the vast cultural, demographic and political changes that twice helped sweep him into office.


He also highlighted themes of national unity, borrowing language that even the most ardent tea party follower would endorse — praising "the patriots of 1776," describing freedom as "a gift from God," endorsing healthy skepticism of "central authority," and describing as "fiction" the notion that government can solve all ills.


But Obama made clear he views government as essential to fix the nation's problems and to guarantee the security of its citizens, reaffirming Democratic ideology stretching from the days of Franklin D. Roosevelt's New Deal.


"Medicare and Medicaid and Social Security, these things do not sap our initiative," he said. "They do not make us a nation of takers. They free us to take the risks that make this country great."


The remarks were an allusion to one of the fiercest arguments of the presidential campaign — when Republican nominee Mitt Romney described 47% of Americans, Obama supporters, as overly reliant on government — as well as to attacks on entitlement programs during recent budget battles in Congress.


Obama became the first president to use an inaugural address to call for an end to discrimination against gays and lesbians, equating it with landmark movements for women's suffrage and African American civil rights.


"Our journey is not complete until our gay brothers and sisters are treated like anyone else under the law," Obama said as the crowd applauded.


Obama, who long said he was evolving on same-sex marriage, waited until his reelection campaign was in full swing last year before he announced his support.


Speaking on Martin Luther King Jr. Day, a federal holiday, Obama alluded to the slain civil rights leader after putting his hand on two Bibles — one owned by King, and the other used at the 1861 inauguration of Abraham Lincoln.


Obama first took the oath of office from Chief Justice John G. Roberts Jr. at the White House on Sunday, when his term officially began. On Monday, Roberts administered the oath again, and the two men spoke slowly and carefully — unlike four years ago, when they mangled the text and had to arrange a private do-over at the White House.


Former Presidents Bill Clinton and Jimmy Carter, both Democrats, and their spouses were among the dignitaries who bundled up in heavy coats on a wintry gray morning to witness the public oath. The other living former presidents, Republicans George H.W. Bush, who was recently released from two months in the hospital, and his son, George W. Bush, were absent. Both issued warm statements of congratulations to the Obamas.


In his address, Obama offered an ideological primer on Democrats' beliefs, rather than specifics of the fights likely to dominate the upcoming session of Congress.


He cited Newtown, referring to the horrific elementary school shooting in Connecticut last month, but did not explicitly mention gun violence or firearms control.


He declared that the nation could not succeed "when a shrinking few do very well and a growing many barely make it," the kind of language that sparked Republican complaints during the presidential race that he was engaging in class warfare. But he did not say how he would rectify the disparity.


And while he emphasized the need to rise above "party or faction," he aimed a series of barely concealed zingers at his opponents, including those who deny climate change. He said failure to respond to that threat "would betray our children and future generations," but offered no clues of what he might do.


"We cannot mistake absolutism for principle," he said in another pointed passage, "or treat name-calling as reasoned debate."


Some Republicans said they searched in vain for olive branches. Sen. John McCain (R-Ariz.), who lost to Obama in 2008, said the president did not reach out to "those on the other side of the aisle in a plea to work together."





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A 'Courage Board' for All Conditions






Rating: 9/10 Nearly flawless; buy it now






It’s easy to guess what The Hovercraft was built for just by looking at it: The short swallowtail and the big blunted nose all scream “powder hound.”


I did my first series of tests in early December up in Lake Tahoe, and there was a lot more crust, ice and grooms than powder, so I took it out without expecting much. I got waaay more than I figured I would: The board held its edge just fine in the groomers, but there was no surprise there. The shock came when I crossed over to the shaded side of the mountain, when the soft groomers turned into icy crud. I was fully expecting the Jones to sketch out and leave me butt-checking all over the place, but The Hovercraft’s edge sliced right into the ice and held it as well as it did the soft stuff. No transition, no adjustments — the board just went from soft snow to ice without skipping a beat.


It was so odd that it took me most of the morning before I really trusted it. But by lunchtime, I was flying down the mountain at speeds I wouldn’t dare with any of the other boards we tested. The board’s great bite is thanks to the Jones’ underfoot camber and so-called Magne-Traction edges, which essentially act like a serrated blade to bite into hard snow. These features combine to give the board a huge amount of precision and control in hard snow.


A few weeks later, I was finally able to take it out on Mt. Shasta’s backcountry to hit some deep stuff. It excelled there as well (entirely as expected) thanks to the rockered and blunted nose, which let the board float on top of the soft stuff, while the short, stiff tail made it easy to kick back and keep the nose up.


Bottom line: I’ve never seen a board perform so well in such a wide range of snow conditions. During my multi-mountain testing session of The Hovercraft snowboard, I let one of my friends ride it. He echoed my own thoughts with one simple statement: “This thing just does whatever you ask it to do.”


WIRED Simply some of the best all-mountain performance I’ve seen. Great float on powder, plus a locked-in grip on ice and crud. Seamlessly transitions from soft to hard snow. Shockingly lightweight construction.


TIRED Blunt nose and swallowtail design means you’re not gonna be riding a lot of switch.







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Sundance 2013: Gravitas Ventures Acquires Three Films from Slamdance






LOS ANGELES (TheWrap.com) – Gravitas Ventures has acquired two documentaries and a comedy from Slamdance, the distributor announced on Monday.


Steven Feinartz’s documentary “The Bitter Buddha,” Michael Urie’s comedy “He’s Way More Famous Than You” and Peter Baxter’s documentary “Wild in the Streets” will be released on video on demand in the next three months in more than 100 million homes in North America.






“The Bitter Buddha,” which profiles alt-comic Eddie Pepitone’s quirky lifestyle and imprint on the comedy world, will debut in select theaters February 15 and go to VOD four days later.


Baxter’s “Wild in the Streets,” which documents a centuries-old sports rivalry between two villages in England on opposite banks of the river Henmore, is set to be released on VOD on April 23. No date was announced for a theatrical release.


And “He’s Way More Famous Than You,” which premiered at Slamdance, will be released on VOD April 8, followed by a theatrical run on May 10. It follows Halley Feiffer, whom Gravitas described as a “once-up-and-coming indie film starlet,” as she strives for Hollywood fame.


“We are thrilled to be working with such an array of talent coming out of Slamdance,” Melanie Miller, vice president of acquisitions at Gravitas, said in a statement. “Nobody channels the cultural zeitgeist quite like Eddie Pepitone, no one with a competitive edge would want to be left out of hundreds of years of bloody town tradition in ‘Wild In The Streets.’ And, who doesn’t want to work and co-star in a movie with Halley Feiffer?”


Movies News Headlines – Yahoo! News





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The Week: A Roundup of This Week’s Science News





“Science,” a colleague once said at a meeting, “is a mighty enterprise, which is really rather quite topical.” He was so right: as we continue to enhance our coverage of the scientific world, we always aim to keep the latest news front and center.




His observation seemed like a nice way to introduce this column, which will highlight the week’s developments in health and science news and glance at what’s ahead. This past week, for instance, the mighty enterprise of science addressed itself to such newsy topics as the flu (there’s still time to get vaccinated!), and mental illness and gun control.


In addition to the big-headline stories that invite wisdom from scientists, each week there is a drumbeat of purely scientific and medical news that emerges from academic journals, fieldwork and elsewhere. These developments, from the quirky to the abstruse, often make their way into the daily news cycle, depending on the strength of the research behind them. (Well, that’s how we judge them, anyway.)


Many discoveries are hard to unravel. “In a way, science is antithetical to everything that has to do with a newspaper,” the same colleague observed. “You couldn’t imagine anything less consumer-friendly.”


Let’s aim to fix that. Below, a selection of the week’s stories.


DEVELOPMENTS


Health


Strange, but Effective


People with a bacterial infection called Clostridium difficile — which kills 14,000 Americans a year — have a startling cure: a transplant of someone else’s feces into their digestive system, which introduces good bacteria that the gut needs to fight off the bad. For some people, antibiotics don’t fix this problem, but an infusion of diluted stool from a healthy person seems to do the trick.


Genetics


Dig We Must



Hillery Metz and Hopi Hoekstra/Harvard University



Evolutionary biologists at Harvard took a tiny species of deer mice, known for building elaborate burrows with long tunnels, and bred it with another species of deer mice, which builds short-tunneled burrows. Comparing the DNA of the original mice with their offspring, the biologists pinpointed four regions of genetic code that help tell the mice what kind of burrow to construct.


Aerospace


Launch, Then Inflate



Uncredited/Bigelow Aerospace, via Associated Press



NASA signed a contract for an inflatable space habitat — roughly pineapple-shaped, with walls of floppy cloth — that will ideally be appended to the International Space Station in 2015. NASA aims to use the pod to test inflatable technology in space, but the company that builds these things, Bigelow Aerospace, has bigger ambitions: think of a 12-person apartment and laboratory in the sky, with two months’ rent at north of $26 million.


Biology


What’s Green and Flies?



Jodi Rowley/Australian Museum



National Geographic reported on an Australian researcher working in Vietnam who discovered a great-looking new species of flying frog. Described as having flappy forearms (the better for gliding), the three-and-a-half-inch-long frog likes to “parachute” from tree to tree, Jodi Rowley, an amphibian biologist at the Australian Museum in Sydney, told the magazine. She named it Helen’s Flying Frog, for her mother.


Privacy


That’s Joe’s DNA!


People who volunteer their genetic information for the betterment of science — and are assured anonymity — may find that their privacy is not a slam dunk. A researcher who set out to crack the identities of a few men whose genomes appeared in a public database was able to do so using genealogical Web sites (where people upload parts of their genomes to try to find relatives) as well as some simple search tools. He was trying to test the database’s security, but even he did not expect it to be so easy.


Genetics


An On/Off Switch for Disease


Geneticists have long puzzled over what it is that activates a disease in one person but not in another — even in identical twins. Now researchers from Johns Hopkins and the Karolinska Institute in Sweden who studied people with rheumatoid arthritis have identified a pattern of chemical tags that tell genes whether to turn on or not. In rheumatoid arthritis, the immune system attacks the body, and it is thought the tags enable the attack.


Planetary Science


That Red Planet


Everybody loves Mars, and we’re all secretly hoping that NASA’s plucky little rover finds evidence of life there. Meanwhile, a separate NASA craft — the Mars Reconnaissance Orbiter, which has been looping the planet since 2006 — took some pictures of a huge crater that looks as if it once held a lake fed by groundwater. It is too soon to say if the lake held living things, but NASA’s news release did include the happy phrase “clues to subsurface habitability.”


COMING UP


Animal Testing


Retiring Chimps



Emily Wabitsch/European Pressphoto Agency



A lot of people have strong feelings about the use of chimpanzees in biomedical and behavioral experiments, and the National Institutes of Health has been listening. On Tuesday, the agency is to release its recommendations for curtailing chimp research in a big way. This will be but a single step in a long process and it will apply only to the chimps the agency owns, but it may well stir big reactions from many constituencies.


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Bank of Japan Moves to Fight Deflation



TOKYO — The Bank of Japan set an ambitious 2 percent inflation target and pledged to ease monetary policy “decisively” by introducing open-ended asset purchases, following intense pressure from the country’s audacious new prime minister, Shinzo Abe, who has made beating deflation a national priority.


In a joint statement with the government, the central bank said it was doubling its inflation target to 2 percent and said it would “pursue monetary easing and aim to achieve this target at the earliest possible time.”


The Bank of Japan also said that it intended to purchase assets indefinitely, promising to stick to a program that has allowed the bank to pump funds into the Japanese economy, even with interest rates at virtually zero. The bank’s board voted to keep its benchmark rate at a range of zero to 0.1 percent.


Since last year, when Mr. Abe was still opposition leader, he has urged the central bank to do more to end deflation, the all-around fall in prices, profit and incomes that has plagued Japan’s economy since the late 1990s. He has stepped up the pressure on the bank after a landslide victory by his Liberal Democratic Party in parliamentary elections in December, which catapulted him to office for the second time since a short-lived stint in 2006-07.


Mr. Abe’s push to increase the monetary supply, among other things, has weakened the yen, a boon to the competitiveness of exporters, which make up much of Japan’s growth. Earlier this month, Mr. Abe also announced a 12 trillion yen emergency stimulus, providing even more tailwind for the Japanese economy. That bright outlook has pushed the Nikkei stock index 20 percent higher since mid-November, when Mr. Abe first campaigned on his expansionary platform.


Mr. Abe’s critics, however, warn that the central bank, which will buy up more government bonds as part of its asset purchase program, will become a printing press for profligate government spending — spending that carries great risks for a country whose public debt is already twice the size of its economy. Critics also say that before flooding a broken system with money, Japan must first tackle structural problems that hurt economic efficiency.


Mr. Abe maintains that deflation will undermine any efforts to grow, and that the government and central bank must act together to get prices rising again. But in a nod to critics, the joint statement said the government would also promote “all possible decisive policy actions for reforming the economic structure” and establish “a sustainable fiscal structure.”


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Gun control draws vigorous debate across California









From shooting ranges to churches, gun control was the subject of vigorous debate over the weekend at various venues across California.


In Sacramento, hundreds rallied in front of the Capitol on Saturday to protest efforts to restrict gun ownership. President Obama has called for an assault weapons ban, a universal background check system for every gun sale and a ban on high-capacity ammunition magazines.


At the Los Angeles Gun Club, range master Joseph Im said the downtown facility had seen an uptick in its ammunition sales since the Sandy Hook shooting and the renewed debate over gun control.





Thomas Brambila, 38, and Tamara Vravis, 43, had come to the range on a first date. Brambila said he had grown up target shooting, although he does not own a gun now because he has young children at home. He called Obama's gun control proposal "misguided."


Vravis said she grew up on a ranch in Minnesota, where guns were common. She agreed with Brambila.


"I think if you really want to get a gun, you can get a gun. It's going to hurt the law-abiding citizens," she said of the move to tighten gun laws.


While some people were celebrating their love of guns, others held events to draw attention to gun violence. A network of churches around the country planned a Gun Violence Prevention Sabbath in response to the Sandy Hook shooting, with services centering on community members who have lost family members to gun violence.


The City of Refuge Church in Gardena held special services Sunday to call for efforts to crack down on gun violence. Hollywood Adventist Church held a smaller gathering of a few dozen Saturday.


Carmen Taylor Jones and Darryl Jones spoke about their 15-year-old daughter, Breon Taylor, who was killed five years ago Saturday when two young men shot through a window into the Lakewood Masonic Lodge, where Breon was one of several hundred young people attending a birthday party. Breon and a 17-year-old boy were killed.


It was the day before Taylor Jones' 45th birthday.


"At that moment, in the twinkling of an eye, everyone's lives, some of their destinies were interrupted," Taylor Jones said.


The gunmen who shot into the party, 16 and 19 at the time, were eventually sentenced to a combined 400 years in prison.


Taylor Jones, who grew up in Watts, said she sees memorials for other young people who were gunned down and worries about the safety of her 15-year-old son.


"When he's with me in South Los Angeles, I almost feel like he's a target, like he has a mark on him," she said.


Taylor Jones said she believes the Sandy Hook massacre got people's attention in a way that individual tragedies like her daughter's death couldn't. She called Obama's gun control proposal "a step in the right direction."


"It's just time for us to have some very serious conversations," she said.


The Sacramento protest was one of dozens held at state capitals nationwide as politicians push new gun laws.


They keep adding more and more laws," said Wes Holst, who hosts a radio show about guns in Santa Cruz. "More laws don't prevent crime."


Some people waved flags or hoisted signs saying "Hands off my guns" and "Gun laws don't stop criminals, bullets do," and many spoke fearfully of restrictions they say would leave them defenseless against criminals or even a government they view with suspicion.


California has some of the toughest gun laws in the country, and there were no firearms to be seen at Saturday's rally. A few people wore empty holsters.


Daniel Silverman, an information technology consultant who lives in Tracy, Calif., said he organized the Sacramento event as part of a grass-roots campaign called Guns Across America. He said the rally was not connected to Gun Appreciation Day, which was started by a Republican consulting firm in Washington.


He said politicians have unfairly singled out firearms as the cause of violence. A gun, he said, is only "a piece of plastic, aluminum and steel that does no harm in the hands of good men and women."


abby.sewell@latimes.com


chris.megerian@latimes.com





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A Google-a-Day Puzzle for Jan. 21











Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.


SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!


Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.


And now, without further ado, we give you…


TODAY’S PUZZLE:



Note: Ad-blocking software may prevent display of the puzzle widget.




Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

Read more by Ken Denmead

Follow @fitzwillie and @geekdads on Twitter.



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Manti Te’o to be interviewed by Katie Couric






NEW YORK (AP) — Notre Dame linebacker Manti Te‘o will be interviewed by Katie Couric, the first on-camera interview given by the All-American since news broke about the dead girlfriend hoax.


Te’o and his parents will appear on Couric’s syndicated talk show Thursday. ABC News announced the interview Sunday, but gave no details as to when it will take place and where.






Te’o gave an off-camera interview with ESPN on Friday night. He insists he was the victim of the hoax, not a participant. The Heisman Trophy runner-up said he had an online romance with a woman he never met and in September was informed that the woman died from leukemia.


Te’o told ESPN that the person suspected of being the mastermind of the hoax has contacted him and apologized.


Entertainment News Headlines – Yahoo! News





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Well: A Check on Physicals

“Go Beyond Your Father’s Annual Physical. Live Longer, Feel Better”

This sales pitch for the Princeton Longevity Center’s “comprehensive exam” promises, for $5,300, to take “your health beyond the annual physical.” But it is far from certain whether this all-day checkup, and others less inclusive, make a meaningful difference to health or merely provide reassurance to the worried well.

Among physicians, researchers and insurers, there is an ongoing debate as to whether regular checkups really reduce the chances of becoming seriously ill or dying of an illness that would have been treatable had it been detected sooner.

No one questions the importance of regular exams for well babies, children and pregnant women, and the protective value of specific exams, like a Pap smear for sexually active women and a colonoscopy for people over 50. But arguments against the annual physical for all adults have been fueled by a growing number of studies that failed to find a medical benefit.

Some experts note that when something seemingly abnormal is picked up during a routine exam, the result is psychological distress for the patient, further testing that may do more harm than good, and increased medical expenses.

“Part of the problem of looking for abnormalities in perfectly well people is that rather a lot of us have them,” Dr. Margaret McCartney, a Scottish physician, wrote in The Daily Mail, a British newspaper. “Most of them won’t do us any harm.”

She cited the medical saga of Brian Mulroney, former prime minister of Canada. A CT scan performed as part of a checkup in 2005 revealed two small lumps in Mr. Mulroney’s lungs. Following surgery, he developed an inflamed pancreas, which landed him in intensive care. He spent six weeks in the hospital, then was readmitted a month later for removal of a cyst on his pancreas caused by the inflammation.

The lumps on his lungs, by the way, were benign. But what if, you may ask, Mr. Mulroney’s lumps had been cancer? Might not the discovery during a routine exam have saved his life?

Logic notwithstanding, the question of benefits versus risks from routine exams can be answered only by well-designed scientific research.

Defining the value of a routine checkup — determining who should get one and how often — is especially important now, because next year the Affordable Care Act will add some 30 million people to the roster of the medically insured, many of whom will be eligible for government-mandated preventive care through an annual exam.

Dr. Ateev Mehrotra of the University of Pittsburgh School of Medicine, who directed a study of annual physicals in 2007, reported that an estimated 44.4 million adults in the United States undergo preventive exams each year. He concluded that if every adult were to receive such an exam, the health care system would be saddled with 145 million more visits every year, consuming 41 percent of all the time primary care doctors spend with patients.

There is already a shortage of such doctors and not nearly enough other health professionals — physician assistants and nurse practitioners — to meet future needs. If you think the wait to see your doctor is too long now, you may want to stock up on some epic novels to keep you occupied in the waiting room in the future.

Few would challenge the axiom that an ounce of prevention is worth a pound of cure. Lacking incontrovertible evidence for the annual physical, this logic has long been used to justify it:

¶ If a thorough exam and conversation about your well-being alerts your doctor to a health problem that is best addressed sooner rather than later, isn’t that better than waiting until the problem becomes too troublesome to ignore?

¶ What if you have a potentially fatal ailment, like heart disease or cancer, that may otherwise be undetected until it is well advanced or incurable?

¶ And wouldn’t it help to uncover risk factors like elevated blood sugar or high cholesterol that could prevent an incipient ailment if they are reversed before causing irreparable damage?

Even if there is no direct medical benefit, many doctors say that having their patients visit once a year helps to maintain a meaningful relationship and alert doctors to changes in patients’ lives that could affect health. It is also an opportunity to give patients needed immunizations and to remind them to get their eyes, teeth and skin checked.

But the long-sacrosanct recommendation that everyone should have an annual physical was challenged yet again recently by researchers at the Nordic Cochrane Center in Copenhagen.

The research team, led by Dr. Lasse T. Krogsboll, analyzed the findings of 14 scientifically designed clinical trials of routine checkups that followed participants for up to 22 years. The team found no benefit to the risk of death or serious illness among seemingly healthy people who had general checkups, compared with people who did not. Their findings were published in November in BMJ (formerly The British Medical Journal).

In introducing their analysis, the Danish team noted that routine exams consist of “combinations of screening tests, few of which have been adequately studied in randomized trials.” Among possible harms from health checks, they listed “overdiagnosis, overtreatment, distress or injury from invasive follow-up tests, distress due to false positive test results, false reassurance due to false negative test results, adverse psychosocial effects due to labeling, and difficulties with getting insurance.”

Furthermore, they wrote, “general health checks are likely to be expensive and may result in lost opportunities to improve other areas of health care.”

In summarizing their results, the team said, “We did not find an effect on total or cause-specific mortality from general health checks in adult populations unselected for risk factors or disease. For the causes of death most likely to be influenced by health checks, cardiovascular mortality and cancer mortality, there were no reductions either.”

What, then, should people do to monitor their health?

Whenever you see your doctor, for any reason, make sure your blood pressure is checked. If a year or more has elapsed since your last blood test, get a new one.

Keep immunizations up to date, and get the screening tests specifically recommended based on your age, gender and known risk factors, including your family and personal medical history.

And if you develop a symptom, like unexplained pain, shortness of breath, digestive problems, a lump, a skin lesion that doesn’t heal, or unusual fatigue or depression, consult your doctor without delay. Seek further help if the initial diagnosis and treatment fails to bring relief.

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