Breakaway Oil Rig Runs Aground in Gulf of Alaska

Petty Officer 3rd Class Jonathan Klingenberg/U.S. Coast Guard

A view of the Kulluk aground southeast of Sitkalidak Island. The grounding was only the latest of the problems Shell has run into in seeking to drill north of Alaska.

WASHINGTON — One of Shell Oil’s two Arctic drilling rigs is beached on an island in the Gulf of Alaska, threatening environmental damage from a fuel spill and calling into question Shell’s plans to resume drilling in the treacherous waters north of Alaska in the summer.

The rig, the Kulluk, broke free from a tow ship in stormy seas and ran aground Monday night. The Coast Guard was leading an effort to keep its more than 150,000 gallons of diesel fuel and lubricants from spilling onto the rocky shoreline.

At a news conference in Anchorage on Tuesday afternoon, Capt. Paul Mehler III, the federal on-scene coordinator, said that a reconnaissance flight showed the Kulluk was upright and stable, with no significant motion.

“The results are showing us that the Kulluk is sound,” Captain Mehler said. “No sign of breach of hull, no sign of release of any product.” He said the response team hoped to get salvage experts aboard the ship to get a better picture of damage.

Steven Russell of the Alaska Department of Environmental Conservation said that, so far, there was no sign of harm to the environment or wildlife.

The Kulluk’s 18 crew members had been evacuated by Coast Guard helicopters on Saturday after the rig first went adrift in high winds and rough seas.

The grounding was the latest in a series of mishaps to befall Shell’s ambitious plans to prospect for oil in the Beaufort and Chukchi Seas off the North Slope of Alaska.

Shell halted drilling for oil in September after equipment failures, unexpected ice floes, operational missteps and regulatory delays forced the company to scale back its plans.

Its drilling rigs completed two shallow pilot holes and left the Arctic in late fall to return to Seattle for maintenance work but have encountered problems in transit.

If the Kulluk, which Shell upgraded in recent years at a cost of nearly $300 million, is wrecked or substantially damaged, it will be hard for the company to find a replacement and receive the numerous government permits needed to resume drilling in July, as planned.

Under Department of Interior rules governing Arctic drilling, the company must have two rigs on site at all times to provide for a backup vessel to drill a relief well in case of a blowout, an uncontrolled escape of oil or gas.

A separate containment system designed to collect oil in the case of a well accident failed during testing, preventing Shell from drilling into oil-bearing formations during its abbreviated exploration season last summer and fall. Shell’s Alaska vice president, Pete Slaiby, said he could not discuss the latest accident, saying that company officials were working with a Coast Guard-directed unified command and could not comment separately.

An official involved in the response operation, who spoke on the condition of anonymity because he was not authorized to comment, said: “We don’t know about the damage. It’s too dark. The weather is horrendous.” The official said that when a helicopter flew over the rig Monday night: “It looked upright about 1,600 feet off the beach. There was no sign of any spill.” The official said the fuel tanks on the vessel were well protected inside the hull, making a spill unlikely.

The Kulluk, which does not have a propulsion system of its own, ran into trouble late last week when its tow ship, the Aiviq, lost engine power and the towline separated. A Coast Guard cutter and other ships arrived, and crews struggled through Monday, in seas up to 35 feet, to reconnect tow lines to the rig, succeeding several times. But each time the lines separated.

On Monday night, the Kulluk, 266 feet in diameter, broke free from one tow ship and the Coast Guard ordered a second ship to disconnect, fearing for the safety of its crew.

The Kulluk is sitting on the southeast coast of Sitkalidak Island, an uninhabited island separated by the Sitkalidak Strait from the far larger Kodiak Island to the west. The nearest town, Old Harbor, is across the strait on Kodiak Island; it has a population of about 200 people. The strait is home to a threatened species of sea lion.

Clifford Krauss contributed reporting.

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USC's dreadful performance is perfect way to conclude imperfect season

EL PASO — A football season that once swaggered through the warmth of a No. 1 ranking has curled up and expired in a cold, remote desert, buffeted by a chilled and foreboding wind.

The kid coach is bundled in a black hoodie and wearing sunglasses. He is standing 10 yards from most of his team. He is hunched over a play card, huddled into himself, alone.

The kid quarterback is battered by the wind, perplexed by the defense and wandering the sidelines looking for comfort or instruction. He receives neither and wanders alone.

The athletic director who has said he is "150%" behind this mess is on speed dial, but he cannot be reached for comment, which could mean nothing or everything. In offering his unwavering and unconditional support of the most underachieving team in college football history, he, too, could be alone.

Happy New Year's Eve, USC football fans. Are you ready for the mother of all hangovers?

Playing a losing team from a weakened conference in a secondary bowl game Monday, the Trojans did worse than simply lose. They didn't even show up.

In a 21-7 loss to Georgia Tech, Coach Lane Kiffin was distant, quarterback Max Wittek was despairing, the defense was battered for nearly 300 rushing yards, and even their scarf-swaddled fans finally had enough. In the final minutes of the game, Trojans fans rained boos down upon Georgia Tech for having the nerve to call timeout and extend their agony.

This wasn't just one bad game; this was the end of a season filled with bad games, the last milepost in arguably the most unsightly journey ever taken by a football team in NCAA history.

The Trojans went from No. 1 in the country to out of the rankings entirely, the first time this has happened in 48 years. The Trojans went from talk of an undefeated season to six losses, including five in the last six games. The Trojans went from Hollywood to El Paso to a tiny Sun Bowl conference room in which Kiffin tried to explain it all.

"A very surprising day," he said. "Obviously, it starts with the head coach."

Many believe this should be the end of the head coach. Even though Athletic Director Pat Haden assured me on Nov. 17 that Kiffin was returning next season and that he was "150%" behind the coach, many think he could and should change his mind.

Since that statement — oddly coming on the day of the loss to UCLA — the Trojans suffered through questionable play-calling in a loss to Notre Dame and then experienced an awful week here. Georgia Tech walked out of a Sun Bowl banquet because the Trojans showed up late, two Trojans tweeted nasty things about the city of El Paso, and even a giant Trojans thank-you ad purchased for the back page of the sports section of the El Paso Times couldn't fully make amends.

Although USC claimed bowl officials knew about its late banquet arrival, and although USC players aren't the first kids to tweet dumb things, there are no easy explanations about what happened in the week's culminating event. How on earth does a Trojans team supposedly loaded with NFL prospects gain only 205 total yards against a Georgia Tech team that gave up 510 yards to Middle Tennessee State? Or have only two more first downs than punts? Or commit three turnovers, giving them 34 for the season, the most ever for a team with a winning record?

"We had two great weeks of practice. ... I thought our guys were really into it," said Kiffin, shaking his head, showing again the apparent fraying in his connection with his team.

Kiffin later said he was huddled under the hoodie because he didn't want to wear a ski cap. He also said he was wearing sunglasses to hide a tiny bandage, which he said was covering a scrape caused by some horsing around with linebacker Hayes Pullard.

"C'mon, you know that how I looked is not the reason we lost this game," he said.

But all of it contributed to the perception of a coach who is not a strong leader, which is another reason Haden could ultimately change his mind and make a change. This lack of leadership spread to his players, even quarterback Matt Barkley, who began the season as a Heisman Trophy favorite and ended it as a no-show.

Yes, Barkley's season ended when he suffered a sprained shoulder against UCLA. But where was the quarterback on the sidelines Monday when Wittek could have used his counsel? Where was any veteran to support the redshirt freshman when he was clearly lost while completing 14 of 37 passes for 107 yards with one touchdown and three interceptions? And where were the veterans at the start of the fourth quarter, with the Trojans still trailing by only a touchdown, when USC trudged down the field while the Yellow Jackets bounced and danced in unified excitement?

"I never saw this coming," said senior defensive end Wes Horton. "With the talent and coaches we had, I thought we'd have a much better record."

Statements like that, and games like this, are all damning to Kiffin's cause. But remember, the two things that Haden said he liked about Kiffin are still true. Haden said he loves Kiffin's commitment to academics, and two Trojans were sent home from El Paso for academic reasons. Haden also said he loves Kiffin's recruiting, and the Trojans are still scheduled to have one of the nation's top hauls.

"We'll sign the No. 1 class in the country and go back to work," Kiffin said.

For now, that is true, and I wouldn't be surprised if it remained true. But I also wouldn't be surprised if Haden suddenly changes his mind and changes everything. By now, all shock has been drained from college football's most stunning team, its season ending Monday in the chilliest and most desperate of climes, with an embarrassing loss that was no surprise to anybody.

bill.plaschke@latimes.com

twitter.com/billplaschke

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The Best of Exploration: Top 8 Stories of Space Exploration in 2012

Our recap of the year’s best exploratory exploits continues today with a look at the biggest developments in space exploration. 2012 saw the stunning debut of new spacecraft (Curiosity), the continued contributions of geriatric ones (Voyager), and the first full year since the end of the Space Shuttle program. Casey Dreier of The Planetary Society nominated 8 particularly meaningful developments from the last twelve months.

Image: Dreier’s pick for image of the year, a Cassini photograph of Saturn’s north pole through an infrared filter. (Credit: NASA / JPL / SSI / Emily Lakdawalla)

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Hollywood tops Chinese film market in 2012, first time in four years

SHANGHAI (Reuters) – China‘s 2012 box office was dominated by foreign films for the first time in four years as a deal cemented earlier this year saw more Hollywood film screened on the mainland, squeezing out domestic competition.

China’s box office receipts are expected to reach 16.8 billion yuan ($ 2.7 billion) in 2012 and about 8 billion yuan ($ 1.28 billion), or slightly less than half the receipts, are from domestic films, the official People’s Daily reported on Monday, quoting estimates from the State Administration of Radio, Film and Television.

It is the first time in four years that domestic film receipts totaled less than 50 percent of the market and signals that the February trade agreement to allow more Hollywood movies to be screened in China is having a significant impact on the country’s movie industry.

Last year, domestic films made up 54 percent of box office receipts, down slightly from 56 percent in 2010, local media reported. China agreed in February to open its market to more American movies, permitting 14 premium format films such as IMAX or 3D to be exempt from the annual 20 foreign film quota.

Last month, Tian Jin, China’s vice minister of the State Administration of Radio, Film and Television, said the U.S. film industry was reaping massive profits due to the February concession while domestic producers were under pressure.

However, the best-selling film this year is a low-budget, domestically-produced comedy called “Lost in Thailand” about two rival businessmen. The movie drew a bigger audience in China than James Cameron’s “Avatar”, the People’s Daily said.

($ 1 = 6.2335 Chinese yuan)

(Reporting by Melanie Lee; Editing by Matt Driskill)

Movies News Headlines – Yahoo! News

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Employers Must Offer Family Health Care, Affordable or Not, Administration Says

WASHINGTON — In a long-awaited interpretation of the new health care law, the Obama administration said Monday that employers must offer health insurance to employees and their children, but will not be subject to any penalties if family coverage is unaffordable to workers.

The requirement for employers to provide health benefits to employees is a cornerstone of the new law, but the new rules proposed by the Internal Revenue Service said that employers’ obligation was to provide affordable insurance to cover their full-time employees. The rules offer no guarantee of affordable insurance for a worker’s children or spouse. To avoid a possible tax penalty, the government said, employers with 50 or more full-time employees must offer affordable coverage to those employees. But, it said, the meaning of “affordable” depends entirely on the cost of individual coverage for the employee, what the worker would pay for “self-only coverage.”

The new rules, to be published in the Federal Register, create a strong incentive for employers to put money into insurance for their employees rather than dependents. It is unclear whether the spouse and children of an employee will be able to obtain federal subsidies to help them buy coverage — separate from the employee — through insurance exchanges being established in every state. The administration explicitly reserved judgment on that question, which could affect millions of people in families with low and moderate incomes.

Many employers provide family coverage to full-time employees, but many do not. Family coverage is much more expensive, and the employee’s share of the premium is typically much larger.

In 2012, according to an annual survey by the Kaiser Family Foundation, premiums for employer-sponsored health insurance averaged $5,615 a year for single coverage and $15,745 for family coverage. The employee’s share of the premium averaged $951 for individual coverage and more than four times as much, $4,316, for family coverage.

Starting in 2014, most Americans will be required to have health insurance. Low- and middle-income people can get tax credits to help pay their premiums, unless they have access to affordable coverage from an employer.

In its proposal, the Internal Revenue Service said, “Coverage for an employee under an employer-sponsored plan is affordable if the employee’s required contribution for self-only coverage does not exceed 9.5 percent of the employee’s household income.”

The rules, though labeled a proposal, are more significant than most proposed regulations. The Internal Revenue Service said employers could rely on them in making plans for 2014.

In writing the law, members of Congress often conjured up a picture of employees working year-round at full-time jobs. But in drafting the rules, the I.R.S. wrestled with the complex reality of part-time, seasonal and temporary workers.

In addition, the administration expressed concern that some employers might try to evade the new requirements by firing and rehiring employees, manipulating their work hours or using temporary staffing agencies. The rules include several provisions to prevent such abuse.

The law says an employer with 50 or more full-time employees may be subject to a tax penalty if it fails to offer coverage to “its full-time employees (and their dependents).”

Employers asked for guidance, and the Obama administration provided it, saying that a dependent is an employee’s child under the age of 26.

“Dependent does not include the spouse of an employee,” the proposed rules say.

Thus, employers must offer coverage to children of an employee, but do not have to make it affordable. And they do not have to offer coverage at all to the spouse of an employee.

The administration said that the rules — which apply to private businesses, nonprofit organizations and state and local government agencies — would require changes at many work sites.

“A number of employers currently offer coverage only to their employees, and not to dependents,” the I.R.S. said. “For these employers, expanding their health plans to add dependent coverage will require substantial revisions to their plans.”

In view of this challenge, the agency said it would grant a one-time reprieve to employers who fail to offer coverage to dependents of full-time employees, provided they take steps in 2014 to come into compliance. Under the rules, employers must offer coverage to employees in 2014 and must offer coverage to dependents as well, starting in 2015.

The new rules apply to employers that have at least 50 full-time employees or an equivalent combination of full-time and part-time employees. A full-time employee is a person employed on average at least 30 hours a week. And 100 half-time employees are considered equivalent to 50 full-time employees.

Thus, the government said, an employer will be subject to the new requirement if it has 40 full-time employees working 30 hours a week and 20 half-time employees working 15 hours a week.

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Frequent Flier: An Environmentalist Weighs the Fallout of Flying

Ami Vitale

M. Sanjayan, the lead scientist for The Nature Conservancy, at Firehole River in Yellowstone National Park.

I FLY a lot. And honestly, flying now is a means to an end, although I used to enjoy it. It’s not that I hate it or am paranoid. It’s just that it’s a chore.

Q. How often do you fly for business?

A. Once or twice a week, mostly domestic, but also international about once a month.

Q. What’s your least favorite airport?

A. I hate to say it and know I will get criticized, but it’s Denver International. It should be a great airport, but it isn’t. There are no amenities, no decent meals, no nothing.

Q. Of all the places you’ve been, what’s the best?

A. East Africa. It’s where humans evolved, and it always feels like a homecoming to me. The temperature, the way it looks, the gestalt rekindles a cellular memory that when I’m there I’m in my ancestral home. I think it’s where humans really belong.

Q. What’s your secret airport vice?

A. I catch up on TV shows that I can’t watch at any other time. I’ve watched entire seasons of “Breaking Bad,” “Homeland” and “Downton Abbey” all in one trip.

As the lead scientist for the Nature Conservancy, I am fully aware of the ramifications of flying and its effect on the environment, but sometimes I have to do it. I do always ask myself the question: When I get to my destination, what can I deliver? In other words, is it really important for me to be someplace?

If not, I’m not going to go. I don’t go to meetings, conferences or events unless if I have a very specific role. And then, of course, there’s a personal toll. Flying can be tough on the body and spirit, even if you take good care of yourself.

I love seeing kids take their first flight. It can be so cool to fly as a kid, even today with all the hassle and limited service.

The first time I got to fly was as a 5-year-old on a KLM DC-8 from Colombo in Sri Lanka to Amsterdam. It was a huge thrill. My dad gave me the window seat and I stayed awake for as long as I could, following our path over darkened Asia and then Europe.

As I remember it, the food was fantastic. It was served in a tray that was partitioned into little quadrants. We ate with forks and knives, not with our hands as we did at home in Sri Lanka. Cheese was wrapped in foil, chocolate came in a Delft blue wrapper with a windmill stamped on it, and the juice wasn’t straight from an orange but a box. It was such a big deal to eat like a Westerner.

Since I often travel to remote locations, I rarely carry luggage. I want everything I need close at hand and I hate having to wait and guess whether my luggage will make it. If I really need something I don’t have, I can usually buy it locally. Occasionally, I don’t have a choice because a trip may be too long or too complicated for me to avoid taking my own gear. One time, I was particularly thankful that I put a red jersey in my carry-on.

A few years ago in Alaska, I was stranded with a Discovery Channel crew. We were on a sandy island on the Tana River in the gigantic Wrangell-St. Elias wilderness. The river was running ragged with heavy glacial melt and our rafts were no match for the white water.

We were drenched and miserable. To perhaps catch a passing plane’s attention, I actually wrote a message out on the sand beach with a big stick, just like you see in the movies. When I did see a plane coming, I whirled my red jersey over my head to catch the eye of the bush pilot.

The plane came in very low, the pilot read the message in the sand about our need for help, and then he tossed out a radio and a note, wrapped in his rain jacket. It was amazing. We used the radio to talk to him, and then we arranged a pickup.

The funny thing was that when I was writing out the message in the sand, which gave our GPS coordinates and pickup date, everyone who was with me had advice about what I should say, how big the letters should be, how to make it visible and so on. I mean, really?

Flagging down flying aircraft while you’re on an island is not as common as hailing a cab in rush hour. But everyone had an opinion.

As a scientist, I have to replicate experiments. This is one I don’t really want to repeat ever again.

By M. Sanjayan, as told to Joan Raymond. E-mail: joan.raymond@nytimes.com

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Congress edges closer to 'fiscal cliff' deal but can't close it

WASHINGTON — Democrats and Republicans on Capitol Hill inched toward a compromise to avert part of the so-called fiscal cliff but remained unable to close a deal as each side struggled with internal tensions as well as the remaining gap between them.

Lawmakers have been trying to beat a deadline of midnight Monday, when tax rates are scheduled to go up for the vast majority of Americans. But they could continue chasing a deal for days — even until the new Congress is sworn in at noon Thursday. After that, the political dynamics could shift with the entrance of new members.

If Congress fails to act, the combination of new taxes and sharp cuts in defense spending and domestic programs, which also would take effect with the new year, could tip the economy back into recession, economists have warned.

On Sunday, talks hit a standstill early in the day after Senate Republican leader Mitch McConnell of Kentucky proposed slowing Social Security cost-of-living increases as part of the spending package. Democrats rejected the idea, and many Republicans quickly disavowed it.

In response to a request from McConnell, the Obama administration assigned Vice President Joe Biden to broker further negotiations.

"I'm willing to get this done, but I need a dance partner," McConnell said on the Senate floor. "The sticking point appears to be a willingness, an interest, or courage to close the deal."

Biden and McConnell talked by phone throughout the afternoon as the two sides appeared to close in on a potential compromise.

Republicans have said they are willing to raise taxes on wealthier households while stopping the tax increases for most Americans. The two sides have not agreed on an income threshold for the tax increases. Republicans suggested starting about $550,000 in taxable income for couples and $450,000 for single households. The most recent offer from Democrats had set the tax level slightly lower, about $450,000 for couples and $360,000 for singles.

But Republicans were also seeking to preserve inheritance taxes at the current rate of 35%, while Democrats have sought to raise them. Republicans want to keep the automatic spending cuts in place for now, while Democrats suggest easing them. Democrats also want to continue long-term unemployment benefits as part of the year-end package.

Other sticking points remain over adjustments to the rates Medicare pays doctors and fixing the tax code to protect middle-income Americans from the alternative minimum tax, which was designed to prevent tax avoidance by the wealthy. Both provisions involve laws that are not indexed for inflation and have required annual adjustments by Congress.

The closer the two sides edged toward compromise Sunday, the more divisions within their ranks became apparent.

Republican senators, worried they would be blamed for harming seniors, openly revolted once the McConnell proposal to trim Social Security benefits became public.

After a closed-door meeting, Sen. John McCain (R-Ariz.) articulated the public relations challenge the proposal posed his party: "What [Democrats] are saying now is, 'Republicans want to preserve tax breaks for rich people and give up seniors' Social Security.' It should be off the table. And I think most Republicans believe it should be off the table."

"I'm not a fan," said retiring Sen. Olympia J. Snowe (R-Maine). "I don't think it should be part of it, and I think there are others who shared that view."

Democrats rejected the proposal. An aide, speaking on the condition of anonymity to discuss the talks, said Senate Majority Leader Harry Reid (D-Nev.) "was taken aback and disappointed" by the idea. "We feel we are further apart than we were 24 hours ago."

Adjusting the cost of living for recipients of government benefits, including Social Security, had been offered by President Obama in talks with House Speaker John A. Boehner (R-Ohio) when they were negotiating a broader deficit reduction deal. But Democrats have rejected including the idea in the more limited package now under discussion.

At the same time, some Democrats worried that Biden, who has closed several deals before with McConnell, might be too eager to compromise compared with Reid. White House officials have been more worried than many congressional Democrats about the potential economic damage that the tax cuts and spending reductions could cause.

Obama made clear the line of attack that the White House would use against Republican leaders if Congress could not find a resolution.

"They have had trouble saying yes to a number of repeated offers," Obama said in an interview on NBC's "Meet the Press," which was recorded Saturday.

"If they can't do a comprehensive package of smart deficit reductions, let's at minimum make sure that people's taxes don't go up and that 2 million people don't lose their unemployment insurance."

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A Google-a-Day Puzzle for Dec. 31

Our good friends at Google run a daily puzzle challenge and asked us to help get them out to the geeky masses. Each day’s puzzle will task your googling skills a little more, leading you to Google mastery. Each morning at 12:01 a.m. Eastern time you’ll see a new puzzle posted here.

SPOILER WARNING:
We leave the comments on so people can work together to find the answer. As such, if you want to figure it out all by yourself, DON’T READ THE COMMENTS!

Also, with the knowledge that because others may publish their answers before you do, if you want to be able to search for information without accidentally seeing the answer somewhere, you can use the Google-a-Day site’s search tool, which will automatically filter out published answers, to give you a spoiler-free experience.

And now, without further ado, we give you…

TODAY’S PUZZLE:

Note: Ad-blocking software may prevent display of the puzzle widget.

Ken is a husband and father from the San Francisco Bay Area, where he works as a civil engineer. He also wrote the NYT bestselling book "Geek Dad: Awesomely Geeky Projects for Dads and Kids to Share."

Read more by Ken Denmead

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UK “X Factor” winner regains top chart spot

LONDON (Reuters) – James Arthur, winner of this year’s British version of the “X Factor” TV talent show, saw his debut single climb back to number one in the British pop charts on Sunday.

Arthur’s “Impossible” shot straight to the top earlier this month but was overtaken last week by a tribute song to the victims of the 1989 Hillsborough football stadium disaster, “He Ain’t Heavy, He’s My Brother”, a version of the ballad that was a worldwide hit for The Hollies.

That song has now slipped to fifth position, according to the Official Charts Company listings.

“Scream and Shout” by will.i.am, featuring Britney Spears, stayed at two while Psy’s monster video hit “Gangnam Style” was up three places to third.

In the album charts, British singer Emeli Sande stayed top with “Our Version Of Events”, with Olly Murs‘ “Right Place, Right Time” unchanged at two.

Rihanna was up three places to third with “Unapologetic”.

(Reporting by Stephen Addison; Editing by Alison Williams)

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Dr. Rita Levi-Montalcini, a Revolutionary in the Study of the Brain, Dies at 103

Fabio Campana/European Pressphoto Agency

Dr. Rita Levi-Montalcini in 2007. She discovered chemical tools the body uses to direct cell growth and build nerve networks.

Dr. Rita Levi-Montalcini, a Nobel Prize-winning neurologist who discovered critical chemical tools that the body uses to direct cell growth and build nerve networks, opening the way for the study of how those processes can go wrong in diseases like dementia and cancer, died on Sunday at her home in Rome. She was 103.

Her death was announced by Mayor Gianni Alemanno of Rome.

“I don’t use these words easily, but her work revolutionized the study of neural development, from how we think about it to how we intervene,” said Dr. Gerald D. Fishbach, a neuroscientist and professor emeritus at Columbia.

Scientists had virtually no idea how embryo cells built a latticework of intricate connections to other cells when Dr. Levi-Montalcini began studying chicken embryos in the bedroom of her house in Turin, Italy, during World War II. After years of obsessive study, much of it at Washington University in St. Louis with Dr. Viktor Hamburger, she found a protein that, when released by cells, attracted nerve growth from nearby developing cells.

In the early 1950s, she and Dr. Stanley Cohen, a biochemist also at Washington University, isolated and described the chemical, known as nerve growth factor — and in the process altered the study of cell growth and development. Scientists soon realized that the protein gave them a new way to study and understand disorders of neural growth, like cancer, or of degeneration, like Alzheimer’s disease, and to potentially develop therapies.

In the years after the discovery, Dr. Levi-Montalcini, Dr. Cohen and others described a large family of such growth-promoting agents, each of which worked to regulate the growth of specific cells. One, called epidermal growth factor and discovered by Dr. Cohen, plays a central role in breast cancer; in part by studying its behavior, scientists developed drugs to combat the abnormal growth.

In 1986, Dr. Levi-Montalcini and Dr. Cohen shared the Nobel Prize in Physiology or Medicine for their work.

Dr. Cohen, now an emeritus professor at Vanderbilt University, said Dr. Levi-Montalcini possessed a rare combination of intuition and passion, as well as biological knowledge. “She had this feeling for what was happening biologically,” he said. “She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was.”

One of four children, Rita Levi-Montalcini was born in Turin on April 22, 1909, to Adamo Levi, an engineer, and Adele Montalcini, a painter, both Italian Jews who traced their roots to the Roman Empire. In keeping with the Victorian customs of the time, Mr. Levi discouraged his three daughters from entering college, fearing that it would interfere with their lives as wives and mothers.

It was not a future that Rita wanted. She had decided to become a doctor and told her father so. “He listened, looking at me with that serious and penetrating gaze of his that caused me such trepidation,” she wrote in her autobiography, “In Praise of Imperfection” (1988). He also agreed to support her.

She graduated summa cum laude from the University of Turin medical school in 1936. Two years later, Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. She began her research anyway, setting up a small laboratory in her home to study chick embryos, inspired by the work of Dr. Hamburger, a prominent researcher in St. Louis who also worked with the embryos.

During World War II, the family fled Turin for the countryside, and in 1943 the invasion by Germany forced them to Florence. The family returned at the close of the war, in 1945, and Dr. Hamburger soon invited Dr. Levi-Montalcini to work for a year in his lab at Washington University.

She stayed on, becoming an associate professor in 1956 and a full professor in 1958. In 1962, she helped establish the Institute of Cell Biology in Rome and became its first director. She retired from Washington University in 1977, becoming a guest professor and splitting her time between Rome and St. Louis.

Italy honored her in 2001 by making her a senator for life.

An elegant presence, confident and passionate, she was a sought-after speaker until late in life. “At 100, I have a mind that is superior — thanks to experience — than when I was 20,” she said in 2009.

She never married and had no children. In addition to her autobiography, she was the author or co-author of dozens of research studies and received numerous professional awards, including the National Medal of Science.

“It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain,” Dr. Levi-Montalcini wrote in her autobiography, “and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development.”

This article has been revised to reflect the following correction:

Correction: December 30, 2012

An earlier version of this obituary misstated the year Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. It was 1938, not 1936.

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